Table I.

Patient characteristics and treatment outcome.

Pt #	Age (YR), Sex	Underlying disease	Immunosuppressive medications within 1 month of fungal diagnosis	Fungal Organism	Organ System	Diagnosis Method	Treatment	Initial Radiologic Response	Outcome
01	19, M	19, ALL, second CNS relapse	Prednisone taper, high dose methotrexate	Aspergillus fumigatus	Brain, Lungs, Kidney	Culture	AmB voriconazole micafungin; continues on voriconazole 18 M post-transplant	Improvement in lung and CNS disease after 1 month	Alive with resolving lesions 2 yrs s/p BMT
02	15, M	ALL, second marrow relapse	tacrolimus (taper), prednisone 1mg/kg	Rhizopus,, Candida, Acremonium	Brain, Sinus, Lung	Culture	voriconazole, caspofungin posaconazole	Continued decrease in frontal lobe and sinus lesions	Clinical response to therapy but died of ALL relapse
03	11, M	ALL, relapsed, not in remission	Clofarabine, Etoposide, Cyclophosphamide	Rhizopus	Brain, Sinus	Pathology, Culture	voriconazole AmB micafungin caspofungin	Progressive disease over first month, with improvement seen after 2nd month	Died of intracranial hemorrhage, possibly related to fungus
04	12, F	Posterior fossa ependymoma, post-surgical resection	none	Aspergillus fumigatus	Cerebellum, 3rd ventricle, spinal cord	Pathology, Culture, PCR	AmB caspofungin, voriconazole, posaconazole; total therapy for 10 years		Clinical response; disease free and off therapy for 2 years