Table 2.

Sensitivity and Specificity of Various Cut-Off Scores: Original [15], Japanese [16], and Canadian Analyses

QLQ-C30 Domain	SCNS-SF34 Item	Cut-Off	Cohort	Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value
Physical Function	1Work around the home 2Feeling unwell a lot of the time	80	Original	0.65	0.83	0.55	0.89
			Japanese	0.40	0.92	0.63	0.82
			Canadian1 Canadian2	0.77 0.79	0.56 0.51	0.52 0.34	0.80 0.88
		90	Original	0.85	0.58	0.39	0.92
			Japanese	0.85	0.65	0.45	0.93
			Canadian1 Canadian2	0.95 0.91	0.28 0.23	0.45 0.28	0.89 0.89
Role Function	1Work around the home 2Not being able to do the things you used to do	80	Original	0.69	0.79	0.50	0.89
			Japanese	0.69	0.79	0.52	0.88
			Canadian1 Canadian2	0.91 0.94	0.26 0.32	0.43 0.54	0.82 0.87
		90	Original	0.85	0.69	0.46	.94
			Japanese	0.85	0.62	0.43	0.93
			Canadian1 Canadian2	0.97 0.99	0.13 0.16	0.41 0.50	0.89 0.94
Emotional Function	1Feelings of sadness 2Feeling down or depressed	90	Original	0.89	0.53	0.48	0.91
			Japanese	0.84	0.60	0.58	0.86
			Canadian1 Canadian2	0.90 0.92	0.43 0.43	0.37 0.38	0.92 0.94
		100	Original	0.94	0.35	0.41	0.93
			Japanese	0.92	0.42	0.51	0.89
			Canadian1 Canadian2	0.98 1.00	0.22 0.23	0.32 0.32	0.97 1.00
Global Health/QOL	Feeling unwell a lot of the time	70	Original	0.71	0.69	0.52	0.84
			Japanese	0.86	0.56	0.33	0.94
			Canadian	0.96	0.34	0.32	0.96
		80	Original	0.89	0.58	0.50	0.91
			Japanese	0.89	0.45	0.29	0.94
			Canadian	0.98	0.24	0.30	0.97
Pain	Pain	20	Original	0.66	0.84	0.64	0.85
			Japanese	0.70	0.81	0.62	0.86
			Canadian	0.90	0.46	0.32	0.95
		10	Original	0.91	0.66	0.54	0.95
			Japanese	0.93	0.54	0.47	0.94
			Canadian	0.95	0.26	0.26	0.95
Fatigue	Lack of energy/ tiredness	30	Original	0.77	0.71	0.73	0.75
			Japanese	0.86	0.62	0.54	0.90
			Canadian	0.94	0.32	0.44	0.91
		20	Original	0.91	0.55	0.68	0.86
			Japanese	0.97	0.42	0.46	0.97
			Canadian	0.99	0.19	0.40	0.96

¹Using same item as Original and Japanese data;

²Using Canadian item with highest AUC