Table 3.
Mean QLQ-C30 Score Changes [Effect Size] (95% Confidence Intervals) Associated with Changes in Supportive Care Needs
| Physical Function* |
Role Function* |
Emotional Function* |
Global Health/QOL* |
Pain^ | Fatigue^ | |
|---|---|---|---|---|---|---|
| SCNS-34 Improved | ||||||
| Some Unmet Need to Not Applicable |
n=50
17.3 [6.60] (12.2 to 22.4) p<0.001 |
n=50
32.3 [7.90] (24.3 to 40.4) p<0.001 |
n=25
16.7 [4.10] (8.8 to 24.6) p<0.001 |
n=34
20.1 [5.50] (12.9 to 27.3) p<0.001 |
n=36
−31.0 [−6.70] (−40.1 to −21.9) p<0.001 |
n=27
−25.9 [−5.80] (−34.8 to −17.1) p<0.001 |
| Some Unmet Need to Satisfied |
n=58
15.2 [5.50] (9.8 to 20.6) p<0.001 |
n=58
18.1 [4.20] (9.7 to 26.5) p<0.001 |
n=33 5.8 [1.70] (−0.8 to 12.4) p=0.10 |
n=35
9.8 [3.00] (3.3 to 16.2) p=0.006 |
n=42
−28.6 [−5.60] (−38.5 to −18.7) p<0.001 |
n=74
−19.0 [−6.90] (−24.4 to −13.6) p<0.001 |
| SCNS-34 Worsened | ||||||
| Not Applicable to Some Unmet Need | n=13 3.1 [0.50] (−10.2 to 16.4) p=0.66 |
n =13 −12.8 [−1.40] (−30.6 to 5.0) p=0.18 |
n=26
−21.2 [−3.70] (−32.3 to −10.0) p=0.001 |
n=18
−13.4 [−2.50] (−24.0 to −2.8) p=0.02 |
n=12 15.3 [2.10] (1.2 to 29.4) p=0.06 |
n=8
20.8 [3.70] (9.7 to 32.0) p=0.008 |
| Satisfied to Some Unmet Need | n=41 5.4 [1.50] (−1.6 to 12.4) p=0.14 |
n=41
20.7 [3.60] (9.3 to 32.2) p<0.001 |
n=36
−9.3 [−2.60] (−16.2 to −2.4) p=0.01 |
n=39 −4.9 [−1.30] (−12.1 to 2.3) p=0.19 |
n=37 −0.5 [−0.10] (−8.3 to 7.4) p=0.91 |
n=66 1.5 [0.50] (−4.7 to 7.8) p=0.64 |
| SCNS-34 Unchanged | ||||||
| Not Applicable to Not Applicable |
n=72
6.7 [4.80] (4.0 to 9.5) p<0.001 |
n=72
15.7 [4.50] (8.9 to 22.6) p<0.001 |
n=192
3.4 [3.60] (1.6 to 5.3) p<0.001 |
n=217
6.1 [4.90] (3.6 to 8.5) p<0.001 |
n=122
−2.7 [−2.00] (−5.4 to 0) p=0.05 |
n=52
−6.0 [−2.20] (−11.3 to −0.7) p=0.03 |
| Satisfied to Satisfied |
n=107
4.4 [2.70] (1.2 to 7.6) p=0.008 |
n=107
7.8 [2.50] (1.6 to 14.0) p=0.01 |
n=53 −1.1 [−0.50] (−5.1 to 2.9) p=0.60 |
n=49 6.1 [1.70] (−0.8 to 13.1) p=0.09 |
n=112
−12.9 [−5.80] (−17.3 to −8.6) p<.0.001 |
n=125
−5.6 [−2.80] (−9.6 to −1.7) p=0.006 |
*
For these domains, positive changes reflect improvement in functioning and negative scores reflect worsening in functioning
^
For these domains, positive changes reflect worsening in symptoms and negative scores reflect improvement in symptoms
BOLD: p≤0.05
Gray shading: change in direction contrary to hypothesis