Table 2. Clinical characteristics and laboratory parameters of parents and siblings of children with and without atherogenic dyslipidemia.
| Parents | Siblings | |||
|---|---|---|---|---|
| Variables | of children with atherogenic dyslipidemia(n = 124) | of children without atherogenic dyslipidemia (n = 442) | of children with atherogenic dyslipidemia (n = 43) | of children without atherogenic dyslipidemia (n = 160) |
| Age, (yrs) | 40.0 ± 6.4 | 40.4 ± 5.8 | 11.2 ± 5.8 | 10.2 ± 6.2 |
| BMI, (kg/m2) | 25.5 ± 3.9 | 24.9 ± 4.0 | 21.0 ± 6.2 | 18.7 ± 3.9 |
| Systolic BP (mmHg) | 119.8 ± 13.0 | 119.2 ± 13.2 | 102.3 ± 12.2 | 104.7 ± 12.3 |
| Diastolic BP (mmHg) | 75.7 ± 8.5 | 76.4 ± 9.3 | 63.4 ± 7.2 | 66.4 ± 8.4 |
| Waist circumference (cm) | 93.0 ± 13.0* | 88.9 ± 13.3 | 74.9 ± 25.1 | 60.3 ± 12.8 |
| Plasma lipids (mg/dl) | ||||
| Total cholesterol | 211.8 ± 46.2 | 205.2 ± 38.7 | 166.9 ± 35.9 | 171.1 ± 38.46 |
| HDL-C | 45.0 ± 12.3*** | 54.2 ± 14.5 | 42.4 ± 9.0 ‡‡‡ | 55.0 ± 12.4 |
| Non HDL-C | 166.8 ± 47.6*** | 150.9 ± 41.8 | 124.4 ± 37.1 | 116.1 ± 36.0 |
| Total triglycerides | 141.5 ± 88.6*** | 103.7 ± 83.3 | 98.7 ± 63.2 ‡‡‡ | 63.7 ± 23.5 |
| LDL-C | 139.0 ± 44.3* | 130.1 ± 34.5 | 104.6 ± 34.1 | 103.3 ± 34.8 |
| ApoB | 94.4 ± 30.1** | 86.7 ± 25.6 | 74.5 ± 24.9 | 73.5 ± 22.8 |
| LDL-C/ApoB | 1.51 ± 0.41 | 1.60 ± 0.56 | 1.49 ± 0.44 | 1.51 ± 0.67 |
| ApoAI | 147.8 ± 32.0*** | 159.1 ± 34.6 | 133.9 ± 27.1 ‡‡‡ | 154.1 ± 31.0 |
| Fasting Blood glucose (mg/dl) | 83.2 ± 19.7*** | 75.9 ± 13.3 | 77.7 ± 12.8 | 72.0 ± 11.4 |
| Insulin (μU/ml) | 9.68 ± 14.0 | 7.93 ± 4.80 | 8.5 ± 7.2 | 6.95 ± 5.35 |
| HOMA-IR | 2.54 ± 7.31 | 1.55 ± 1.28 | 1.81 ± 1.97 | 1.30 ± 1.07 |
| hs-CRP (mg/dl) | 0.11 (0.04–0.29) | 0.09 (0.03–0.22) | 0.04 (0.01–0.11) | 0.05 (0.01–0.14) |
| Adiponectin (μg/ml) | 3.44 (2.22–4.88) | 3.20 (2.09–5.46) | —- | —- |
| Metabolic Syndrome, n (%) | 9 (7.2) *** | 12 (2.7) | 5 (11.6) ‡‡‡ | —- |
BMI, body mass index; BP, blood pressure; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; ApoB, apolipoprotein B; ApoAI, apolipoprotein AI; hs-CRP, high sensitivity C Reactive Protein; HOMA-IR, homeostasis model assessment of IR index. hs-CRP and adiponectin values are reported as median (interquartile range)
* P<0.05;
** p<0.01;
*** p<0.001 between parents
‡‡ p<0.01;
‡‡‡ p<0.001 between siblings