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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Pediatr Blood Cancer. 2015 Mar 1;62(6):964–969. doi: 10.1002/pbc.25410

Figure 4. Emergence of a CD22 Dim Population in a Patient with MLL-Rearranged ALL Treated with Anti-CD22 Targeted Therapy.

Figure 4

A 1 year old with MLL-rearranged ALL was treated with an anti-CD22 immunotoxin. A subpopulation of CD22 dim blasts was detectable on the pre-treatment sample (median site density 1,643) (A). An initial dramatic reduction in circulating lymphoblasts was followed by emergence of a CD22 dim blast population (median site density 605) (B) despite ongoing therapy.