Table 2.
Association between SNPs at the ADIPOQ loci and colorectal cancer risk among 3,739 cases and 4,184 controls in women from GECCO*
| SNP | EA/NEA | EAF | Age and PCA- adjusted OR (95% CI) per allele† |
P† | Multivariable-adjusted OR (95% CI) per allele‡ |
P‡ | Pheterogeneity§ |
|---|---|---|---|---|---|---|---|
| rs1063539 | C/G | 0.11 | 0.96 (0.86 to 1.07) | 0.50 | 0.96 (0.86 to 1.08) | 0.51 | 0.45 |
| rs16861194 | G/A | 0.08 | 1.04 (0.91 to 1.18) | 0.57 | 1.04 (0.92 to 1.19) | 0.53 | 0.89 |
| rs7615090 | G/T | 0.13 | 1.01 (0.88 to 1.15) | 0.92 | 1.00 (0.87 to 1.15) | 0.95 | 0.16 |
| rs822394 | A/C | 0.19 | 1.02 (0.94 to 1.11) | 0.65 | 1.02 (0.94 to 1.10) | 0.70 | 0.32 |
| rs17300539 | A/G | 0.07 | 0.98 (0.84 to 1.15) | 0.82 | 0.98 (0.83 to 1.15) | 0.77 | 0.34 |
| rs17366568 | A/G | 0.08 | 1.03 (0.87 to 1.23) | 0.70 | 1.04 (0.87 to 1.24) | 0.67 | 0.20 |
| rs17366743 | C/T | 0.05 | 0.96 (0.78 to 1.18) | 0.71 | 0.95 (0.77 to 1.18) | 0.66 | 0.77 |
| rs6810075 | C/T | 0.35 | 0.99 (0.93 to 1.06) | 0.84 | 1.00 (0.93 to 1.07) | 0.92 | 0.99 |
| rs6773957 | A/G | 0.39 | 1.00 (0.94 to 1.07) | 0.98 | 1.00 (0.93 to 1.06) | 0.89 | 0.13 |
| rs822354 | T/C | 0.32 | 0.99 (0.92 to 1.07) | 0.84 | 0.99 (0.91 to 1.06) | 0.70 | 0.08 |
| rs6444175 | A/G | 0.28 | 1.01 (0.94 to 1.09) | 0.76 | 1.01 (0.94 to 1.08) | 0.85 | 0.34 |
| rs266717 | A/G | 0.50 | 1.02 (0.95 to 1.09) | 0.61 | 1.01 (0.95 to 1.08) | 0.72 | 0.06 |
| rs1426810 | C/T | 0.36 | 1.04 (0.96 to 1.12) | 0.35 | 1.04 (0.96 to 1.12) | 0.35 | 0.33 |
| rs1342387 | A/G | 0.45 | 1.04 (0.97 to 1.10) | 0.28 | 1.03 (0.97 to 1.10) | 0.37 | 0.89 |
| rs12733285 | T/C | 0.29 | 1.04 (0.96 to 1.12) | 0.33 | 1.03 (0.95 to 1.12) | 0.44 | 0.57 |
| rs266729 | G/C | 0.26 | 0.96 (0.89 to 1.04) | 0.35 | 0.96 (0.89 to 1.04) | 0.37 | 0.95 |
| rs1501299 | A/C | 0.28 | 1.02 (0.95 to 1.10) | 0.56 | 1.02 (0.94 to 1.09) | 0.67 | 0.18 |
| rs2241766‖ | G/T | 0.11 | 0.96 (0.87 to 1.06) | 0.42 | 0.96 (0.86 to 1.06) | 0.41 | 0.44 |
| rs1063538 | T/C | 0.39 | 1.00 (0.94 to 1.07) | 0.99 | 0.99 (0.93 to 1.06) | 0.88 | 0.14 |
Abbreviations: CI = confidence interval; EA = effect allele; EAF = effect allele frequency; GECCO = the Genetics and Epidemiology of Colorectal Cancer Consortium; NEA = non-effect allele; OR = odds ratio; PCA = principal component analysis; SNP = single nucleotide polymorphism. A few women had missing information on genotype data of some SNPs: 1 on rs16861194, 23 on rs7615090, 6 on rs822394, 2 on rs17300539, 1 on rs6773957, 1 on rs6444175, 1 on rs266717, 3 on rs1426810, 9 on rs1342387, 1 on rs12733285, 2 on rs1501299, 1 on rs2241766, and 21 on rs1063538.
Additive genetic model was used with adjustment for age and the first 3 principal components from EIGENSTRAT to account for population substructure.
Additionally adjusted for body mass index (<25, 25–30, ≥30 kg/m2), smoking status (past or current smoking vs. never smoking), alcohol consumption (study-specific tertiles), regular use of aspirin or non-steroidal anti-inflammatory drugs, and postmenopausal hormone use (never users, ever users, premenopausal status).
Pheterogeneity across studies in the multivariable-adjusted model.
The proxy rs3774262 (in pair-wise linkage disequilibrium with rs2241766: r2=0.93, D’ = 1.00) was used.