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. 2015 Apr 22;35(16):6307–6317. doi: 10.1523/JNEUROSCI.3481-14.2015

Figure 6.

Figure 6.

Dopaminergic neurons control hyperalgesic priming. A–C, DA lesion 7 d before IL-6 injection blocked hyperalgesic priming (A), and DA lesion 7 d after IL-6 (B) or carrageenan (C) injection reversed the maintenance of hyperalgesic priming. D, This spinally directed DA lesion reduced A11 hypothalamic DA neurons (6-OHDA + desipramine). E–G, DA lesion after IL-6 injection also attenuated the PGE2-induced increase in grimace scores in primed mice (E), contralateral priming (F), and priming in female mice (G, n = 5 per group). n = 6–8 mice per group in A–F. *p < 0.05; **p < 0.01; ***p < 0.001 (two-way ANOVA with Bonferroni post hoc test). Scale bar, 100 μm.