Table 4. Odds of escalation of treatment and odds of using topical anti-inflammatory medication by change in bother score compared to the previous day.

	Escalation of treatment		Use of anti-inflammatory medication
Change in Bother score	Study A (n = 334) Odds ratio (95% CI)	Study B (n = 59) Odds ratio (95% CI)	Study A (n = 334) Odds ratio (95% CI)
No change or improved	1.00	1.00	1.00
1	2.01 (1.85, 2.18)	1.87(1.45, 2.41)	2.42 (2.25, 2.60)
2 or more	3.92 (3.47, 4.43)	3.17 (2.50, 4.03)	4.25 (3.81, 4.75)