Table 5. Mean increase in AE severity scales per unit increase in number of days when treatment escalated and use of a topical anti-inflammatory.

	Study A *Escalation of treatment (95% CI)	Correlation coefficient	Study B * Escalation of treatment (95% CI)	Correlation coefficient	Study A *Anti-inflammatory medication (95% CI)	Correlation coefficient
n	331		59		331
POEM	0.51 (0.33, 0.69); p<0.001	0.527	0.63 (0.10, 1.16); p = 0.021	0.609	0.55 (0.40, 0.71; p<0.001)	0.528
TIS	0.04 (-0.01,0.09); p = 0.138	0.551	0.08 (-0.07, 0.22); p = 0.321	0.61	0.06 (0.02, 0.11; p = 0.003)	0.545
SASSAD	0.43 (0.14, 0.71); p = 0.004	0.762	N/A	N/A	0.53 (0.28, 0.78; p<0.0001)	0.757

*Increase in outcome measure for one unit increase in number of days in the previous week that treatment was escalated of topical anti-inflammatory medication was used. Uses data from weeks 4, 12 and 16