Table 4. Warfarin rats.

Warfarin 1.5 mg/kg i.g. once daily for 3 consecutive days	Bleeding time	Amount of bleeding	PLT before	PLT after	HCT before	HCT after	PT	APTT	TT	FIB
Tail amputation	min	mL	x109/L	x109/L	L/L	L/L	ratio (PR)	ratio	sec	g/L
Control	>60	6.58± 1.2	612± 72	302± 79	0.441± 0.04	0.364± 0.02	<0.05	2.86± 0.42	62± 6	1.5± 0.15
BPC ug	48.6± 15*	5.52± 1.4*	693± 68*	456± 116*	0.461± 0.03	0.417± 0.02*	<0.05	2.81± 0.38	60± 7	1.7± 0.25
BPC ng	>60	5.65± 1.1*	706± 88*	418± 105*	0.465± 0.02	0.420± 0.03*	<0.05	2.83± 0.47	58± 8	1.5± 0.21
L-arginine	>60	7.8± 1.4	638± 89	525± 98*	0.521± 0.06	0.455± 0.04	<0.05	2.03± 0.36	59.9± 8	1.9± 0.19
L-NAME	>60	8.0± 1.8	654± 49	346± 59	0.454± 0.03	0.413± 0.03	<0.05	2.60± 0.39	62.6± 7	1.8± 0.17
L-NAME+ L-arginine	>60	7.0± 1.7	483± 87*	283± 35	0.467± 0.04	0.415± 0.03	<0.05	2.68± 0.34	60.6± 8	1.8± 0.21
L-arginine+ BPC 157 ug	>60	4.9± 0.6*	650± 105	514± 119*	0.476± 0.04	0.472± 0.04	<0.05	2.03± 0.38	59.8± 8	1.6± 0.17
L-NAME+ BPC 157 ug	>60	5.0± 0.9*	637± 88	461± 105*	0.475± 0.04	0.415± 0.02	<0.05	1.74± 0.29	60.1± 7	1.6± 0.15
L-NAME+L-arginine+ BPC 157 ug	>60	4.5± 0.7*	612± 79	493± 113*	0.501± 0.05	0.481± 0.03	<0.05	1.92± 0.31	78.3± 12	1.8± 0.18

Tail amputation, bleeding time, amount of bleeding, PLT, HCT, PT, APTT, TT, FIB values in warfarin rats. Warfarin was given intragastrically (1.5 mg/kg) once daily for 3 consecutive days, with the last challenge was at 3 hours before the bleeding procedure. BPC 157 (10 μg/kg, 10 ng/kg) was given immediately after any warfarin challenge, intragastrically while controls received simultaneously an equivolume of saline (5.0 ml/kg intragastrically). We applied L-NAME (5 mg/kg), L-arginine (100 mg/kg) alone or combined, intraperitoneally, at 30 minutes before amputation. Mean ± SD,

*P<0.05 at least vs. control.