Fig. 2.

Sequence alignment of NPR-1 homologues.

Parasitic nematodes display a conserved phenylalanine in NPR-1 215 in contrast to the dominant amino acid at this position (valine) in C. elegans. Position 215 is boxed in red. Completely and partially conserved amino acid residues are highlighted in yellow and blue, respectively. Di, denotes Dirofilaria immitis; Ov, denotes Onchocerca volvulus; Oo, denotes Onchocerca ochengi; Ll, denotes Loa loa; As, denotes Ascaris suum; Ac, denotes Ancylostoma caninum; Nb, denotes Nippostrongylus brasiliensis; Hc, denotes Haemonchus contortus; Ce, denotes Caenorhabditis elegans; Sr, denotes Strongyloides ratti. All parasitic nematode NPR-1 homologues identified in this study are detailed in Table 2 and Fig. 4.