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. 2015 Apr 21;9:126. doi: 10.3389/fncel.2015.00126

Figure 8.

Figure 8

Confocal microscopy of degu retinal sections immunolabeled with VGLUT1 (red) and PKCα (green). Subcellular localization of VGLUT1 in the outer (A–C) and inner plexiform layers (D–F) of 6- (A,D), 12- (B,E) and 36-month-old (C,F) degu retinas. VGLUT1-immunopositive structures were found in photoreceptor terminals in close apposition to PKCα-positive rod bipolar cell dendrites in the OPL of 6- and 12-month-old degu retinas (A,B). Altogether with the decreased dendritic arbor of the rod bipolar cells the VGLUT1-expression in photoreceptors also decreased in 36-month-old degu retinas (C). VGLUT1-positive large puncta were co-localized with PKCα in the inner part of the IPL indicating VGLUT1 expression in axon terminals of rod bipolar cell in 6- and 12-month-old degu retinas (D,E). In the 36-month-old degu retinas both the arbor of axon terminals of rod bipolar cells and their VGLUT1 expression decreased (F). Abbreviations: OPL—outer plexiform layer; INL—inner nuclear layer; IPL—inner plexiform layer; GCL—ganglion cell layer; PKCα—protein kinase Cα; VGLUT1—vesicular glutamate transporter 1. Scale bar: 10 μm.