. Author manuscript; available in PMC: 2015 Apr 22.

Published in final edited form as: Pediatr Clin North Am. 2013 Jan 17;60(2):367–389. doi: 10.1016/j.pcl.2012.12.003

Table 5.

Evidence of Strategies for Prevention of Neonatal Sepsis

Prevention Strategy	Notes
Lactoferrin	Small studies show reduction of both fungal and bacterial infection. Large studies needed
IVIG	No proven efficacy for prevention of neonatal sepsis
Anti-staphylococcal Monoclonal Antibodies	Monoclonal antibodies against capsular polysaccharide and clumping Factor A have shown no effect in prevention of sepsis. Anti-lipoteichoic acid antibodies may have an effect but further randomized controlled studies are required.
Probiotics	No proven efficacy for neonatal sepsis. Useful as prevention of necrotizing enterocolitis.
GM-CSF/G-CSF¹	No proven efficacy of neonatal sepsis
Glutamine	No proven efficacy of neonatal sepsis
Fluconazole	Efficacious in prevention of Candida sepsis in VLBW infants