FIG 7.

Model for the PATZ1-p53 interaction. p53 and PATZ1 binding sites (boxes labeled p53BS and PATZ1BS, respectively) can be bound by tetrameric p53 (dark gray) after induction of DNA damage or p53 overexpression. PATZ1 proteins (light gray) bind to p53 and inhibit most p53 from binding to DNA. The p53 association can also inhibit the PATZ1 protein from binding the PATZ1 binding site. PATZ1 is a homodimer and can also form heterodimers with the PATZ1Alt variant, which does not directly contact p53. PATZ1 homo- or heterodimerization requires the N-terminal BTB domain.