Table 2.

Mean cohort change from baseline at 15 minutes after inhalation of iloprost

Variable, dose	Mean change from baseline (95% CI)	Paired t test P value	Signed-rank test P value
HR, bpm
2.5-μg dose	−1.25 (−5.58 to 3.08)	0.517	0.547
First 5-μg dose	−3.50 (−7.64 to 0.64)	0.086	0.109
Second 5-μg dose	0.57 (−3.00 to 1.50)	0.709	0.844
O2 sat, %
2.5-μg dose	−2.13 (−5.77 to 1.52)	0.210	0.375
First 5-μg dose	−2.38 (−3.98 to −0.77)	0.010	0.031
Second 5-μg dose	−2.67 (−6.57 to 1.24)	0.140	0.188
MAP, mmHg
2.5-μg dose	4.75 (−7.90 to 17.40)	0.404	0.469
First 5-μg dose	−4.88 (−12.72 to 2.97)	0.185	0.172
Second 5-μg dose	−4.86 (−14.13 to 4.41)	0.247	0.313
PAP, mmHg
2.5-μg dose	−5.38 (−9.32 to −1.43)	0.015	0.031
First 5-μg dose	−7.00 (−11.14 to −2.86)	0.005	0.008
Second 5-μg dose	−4.71 (−8.44 to −0.99)	0.021	0.031
PCWP, mmHg
2.5-μg dose	−2.00 (−4.33 to 0.33)	0.080	0.125
First 5-μg dose	−0.71 (−2.54 to 1.11)	0.376	0.531
Second 5-μg dose	0.50 (−2.05 to 3.05)	0.636	0.750
CO, L/min
2.5-μg dose	0.39 (−0.13 to 0.91)	0.120	0.156
First 5-μg dose	0.78 (−0.07 to 1.62)	0.068	0.110
Second 5-μg dose	0.71 (0.02–1.41)	0.046	0.031
PVR, dyn·s/cm5
2.5-μg dose	−123.88 (−185.64 to −62.11)	0.002	0.016
First 5-μg dose	−161.88 (−287.83 to −35.92)	0.019	0.039
Second 5-μg dose	−95.00 (−163.31 to −26.69)	0.014	0.031
SVR, dyn·s/cm5
2.5-μg dose	−49.38 (−362.81 to 264.06)	0.721	0.999
First 5-μg dose	−131.75 (−421.91 to 158.41)	0.319	0.250
Second 5-μg dose	−270.43 (−565.93 to 25.07)	0.066	0.078

^NoteBoldface type indicates statistical significance. CI: confidence interval; HR: heartrate; O2 sat: oxygen saturation; MAP: mean arterial pressure; PAP: pulmonary artery pressure; PCWP: pulmonary capillary wedge pressure; CO: cardiac output by thermodilution; PVR: pulmonary vascular resistance; SVR: systemic vascular resistance.