Table 5.
Gastrocnemius muscle artery summary data (pEC50 and Emax) of vasodilatation to MCh from male and female, control and IUGR, sedentary and exercised offspring
| pEC50 | Emax (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| No inhibitors | l-NAME | Apamin + Tram-34 | Indomethacin | No inhibitors | l-NAME | Apamin + Tram-34 | Indomethacin | ||
| Male offspring | |||||||||
| Control sedentary | 7.51 ± 0.16 | 7.73 ± 0.63 | 7.52 ± 0.09 | 7.37 ± 0.18 | 76.03 ± 4.89 | 29.09 ± 6.48*** | 55.96 ± 3.19* | 80.25 ± 7.66 | |
| Control exercised | 7.73 ± 0.26 | 7.73 ± 0.6 | 7.44 ± 0.15 | 7.05 ± 0.23 | 58.88 ± 10.68 | 17.72 ± 6.25** | 39.16 ± 6.72 | 67.17 ± 9.63 | |
| IUGR sedentary | 7.60 ± 0.14 | 8.04 ± 0.61 | 7.63 ± 0.14 | 7.21 ± 0.08 | 71.22 ± 8.12 | 36.6 ± 21.65 | 67.65 ± 0.81 | 87.17 ± 5.28 | |
| IUGR exercised | 7.37 ± 0.09 | ND | 7.19 ± 0.17 | 7.57 ± 0.13 | 89.92 ± 6.82 | 46.06 ± 4.87*** | 42.03 ± 7.13*** | 86.63 ± 4.17 | |
| Female offspring | |||||||||
| Control sedentary | 7.61 ± 0.07 | 7.11 ± 0.18* | 7.45 ± 0.08 | 7.23 ± 0.08 | 93.4 ± 3.47 | 32.61 ± 12.25*** | 70.13 ± 6.33 | 83.84 ± 5.67 | |
| Control exercised | 7.53 ± 0.12 | 7.59 ± 0.42 | 7.29 ± 0.13 | 6.87 ± 0.34 | 92.8 ± 5.49 | 36.85 ± 16.61** | 72.10 ± 3.97 | 70.04 ± 7.17 | |
| IUGR sedentary | 7.29 ± 0.11 | 7.22 ± 0.19 | 7.1 ± 0.1 | 7.43 ± 0.08 | 84.34 ± 4.15 | 51.39 ± 17.62 | 55.16 ± 9.54 | 92.81 ± 4.24 | |
| IUGR exercised | 7.56 ± 0.13 | 7.21 ± 0.30 | 7.28 ± 0.11 | 8.1 ± 0.22 | 70.79 ± 10.87 | 39.26 ± 15.26 | 69.3 ± 6.24 | 92.11 ± 2.48 | |
Data presented as mean ± SEM. ND, not determined. *P < 0.05, **P < 0.01, ***P < 0.001 vs. artery with no inhibitor after Dunnett's post hoc test.