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. 2015 Feb 20;593(Pt 8):1931–1943. doi: 10.1113/jphysiol.2014.285338

Figure 2. Middle cerebral artery (MCA) endothelium-dependent and -independent dilation.

Figure 2

A, MCA endothelium-dependent dilatation to ACh in the absence or presence of l-NAME measured by pressure myography in Eln+/+ and Eln+/– mice (n = 16 per group, significance marks denote a time by group interaction or main effect for group from repeated-measures ANOVAs). B, maximal MCA dilatation to ACh in the absence and presence of l-NAME alone and in combination with the cyclooxygenase inhibitor indomethacin (INDO) in Eln+/+ and Eln+/– mice (n = 6–7 per group). C, MCA endothelium-independent dilatation to sodium nitroprusside in Eln+/+ and Eln+/– mice (n = 10–12 per group). *P < 0.05 vs. Eln+/+ ACh alone, †P < 0.05 vs. Eln+/– ACh alone, ‡P < 0.05 vs. Eln+/+ ACh with l-NAME, §P < 0.05 vs. Eln+/– ACh with l-NAME. Values are mean ± SEM.