Table 1.
Middle cerebral artery and gastrocnemius feed artery characteristics
| MCA | GFA | |||
|---|---|---|---|---|
| Eln+/+ | Eln+/– | Eln+/+ | Eln+/– | |
| Maximal diameter (μm) | 158 ± 4 | 160 ± 5 | 207 ± 4 | 203 ± 4 |
| Wall thickness (μm) | 10 ± 1 | 10 ± 1 | 18 ± 2 | 17 ± 1 |
| Intrinsic stiffness (β) | 10.4 ± 0.9 | 9.6 ± 0.9 | 7.8 ± 0.5 | 9.6 ± 0.5* |
| EC50 (log m) | ||||
| ACh | −7.6 ± 0.3 | −7.5 ± 0.2 | −8.2 ± 0.3 | −7.3 ± 0.4* |
| ACh + l-NAME | — | — | −6.9 ± 0.5 | −7.8 ± 0.5 |
| ACh + l-NAME + INDO | — | — | −6.8 ± 0.5 | −7.3 ± 0.2 |
| ACh + TEMPOL | −6.8 ± 0.4 | −6.8 ± 0.4 | — | — |
| SNP | −6.3 ± 0.4 | −6.2 ± 0.4 | − 8.3 ± 0.3 | −7.6 ± 0.1* |
| Preconstriction (%) | ||||
| ACh | 29 ± 2 | 28 ± 2 | 35 ± 3 | 30 ± 3 |
| ACh + l-NAME | 37 ± 6 | 33 ± 5 | 36 ± 3 | 38 ± 4 |
| ACh + l-NAME + INDO | 38 ± 5 | 45 ± 5 | 45 ± 5 | 46 ± 5 |
| ACh + TEMPOL | 29 ± 4 | 28 ± 3 | — | — |
| ACh + TEMPOL + l-NAME | 34 ± 7 | 36 ± 4 | — | — |
| SNP | 39 ± 4 | 42 ± 5 | 44 ± 6 | 48 ± 7 |
Values are mean ± SEM. MCA, middle cerebral artery; GFA, gastrocnemius feed artery; ACh, acetylcholine; l-NAME, NG-nitro-l-arginine methyl ester; INDO, indomethacin; SNP, sodium nitroprusside. *P < 0.05 vs. Eln+/+ within artery.