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. 2015 Feb 23;593(Pt 8):1945–1963. doi: 10.1113/jphysiol.2014.287599

Figure 10. Gap junction uncouplers 18-β-GA and octanol inhibited IJPs in response to EFS.

Figure 10

A, representative electrical response to EFS (10 Hz, 1 s). IJPs were abolished by 18-β-GA (100 μm) and octanol (700 μm) B, summary of average IJP amplitudes under control conditions (l-NNA and atropine present) and in the presence of 18-β-GA (40 μm) (C) and octanol (700 μm) (D). Note that IJP amplitude was reduced at all frequencies tested, even with the lower concentrations of both drugs, except for the response to the 1 P stimulus in the presence of 18-β-GA (n = 6). Higher concentrations of both uncouplers blocked IJPs. E, summary of the average number of action potentials before and after EFS in control and in the presence of 18-β-GA (40 μm). Note the marked decrease in post-stimulus action potentials in the presence of 18-β-GA (40 μm; each bar in the graph represents the average number of action potentials within 10 s after EFS). F, summary of the average number of action potentials in control and in the presence of octanol (300 μm). Note the marked decrease in the action potentials after cessation of EFS in the presence of octanol (300 μm) (each bar in the graph represents the average number of action potentials within 10 s before and after EFS).