Table 2.
Distribution of clinical and pathological parameters and levels of miR-200c and miR-141 in blood
| Parameter | n | miR-200c | Pvalue | miR-141 | P value |
|---|---|---|---|---|---|
| Age (years) | 0.190 | 0.240 | |||
| <55 | 28 | 0.35 (0.72) | 7.71 (12.47) | ||
| ≥55 | 29 | 1.07 (1.74) | 6.4 (15.1) | ||
| Menopause | 0.572 | 0.258 | |||
| Pre-menopausal | 24 | 0.37 (0.68) | 7.8 (12.96) | ||
| Post-menopausal | 33 | 0.97 (1.68) | 6.5 (14.5) | ||
| Histology | 0.140* | 0.712* | |||
| Ductal | 50 | 0.69 (1.36) | 7.26 (14.22) | ||
| Lobular | 5 | 1.3 (1.95) | 10.42 (14.67) | ||
| Other | 2 | 0.01 (0.01) | 0.2 (0.02) | ||
| Histological grade | 0.106* | 0.703* | |||
| 1 | 7 | 1.79 (1.59) | 3.84 (4.92) | ||
| 2 | 25 | 0.36 (0.69) | 4.19 (7.61) | ||
| 3 | 23 | 0.77 (1.74) | 11.72 (19.31) | ||
| TNM Stage | 0.054 | 0.001 | |||
| I-III | 44 | 0.41 (0.83) | 8.81 (15.16) | ||
| IV | 13 | 1.75 (2.22) | 1.06 (3.35) | ||
| Lymph nodes involved | 0.216 | 0.014 | |||
| No | 20 | 1.06 (1.34) | 1.53 (3.41) | ||
| Yes | 37 | 0.53 (1.38) | 10.02 (16.21) | ||
| Hormonal receptors | 0.460 | 0.887 | |||
| Positive | 42 | 0.79 (1.52) | 5.03 (9.35) | ||
| Negative | 14 | 0.44 (0.86) | 13.58 (21.85) | ||
| Oestrogen receptors | 0.460 | 0.887 | |||
| Positive | 42 | 0.79 (1.52) | 5.03 (9.35) | ||
| Negative | 14 | 0.44 (0.86) | 13.58 (21.85) | ||
| Progesterone receptors | 0.653 | 0.371 | |||
| Positive | 29 | 0.59 (1.15) | 5.96 (10.53) | ||
| Negative | 27 | 0.82 (1.61) | 8.46 (16.84) | ||
| HER2 | 0.833 | 0.037 | |||
| Positive | 14 | 0.88 (1.41) | 1.24 (2.13) | ||
| Negative | 42 | 0.64 (1.39) | 9.14 (15.5) | ||
| MIB1 | 0.073 | 0.790 | |||
| <25% | 40 | 0.90 (1.55) | 7.93 (15.24) | ||
| >25% | 14 | 0.19 (0.65) | 5.99 (10.26) | ||
| Type | 0.809* | 0.105* | |||
| Luminal | 32 | 0.71 (1.52) | 6.21 (10.4) | ||
| HER2 | 14 | 0.88 (1.41) | 1.24 (2.13) | ||
| Triple negative | 10 | 0.41 (0.86) | 18.52 (24.35) | ||
| Residual disease | 0.554 | 0.755 | |||
| R0 | 27 | 0.52 (0.97) | 8.69 (17.24) | ||
| R2 | 30 | 0.89 (1.66) | 5.56 (9.73) | ||
| Blood sampling^ | 0.72 | 0.128 | |||
| Before surgery | 17 | 0.24 (0.5) | 8.69 (17.24) | ||
| After surgery | 27 | 0.52 (0.97) | 8.99 (11.59) |
The miRNAs relative expression levels (REL) are shown in arbitrary units. The data represent the mean (standard deviation). n indicates the number of patients with data available. ^Timing of blood sampling before or after surgery is indicated for stages I to III patients only. Mann–Whitney test. *Kruskal-Wallis test.