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. 2015 Apr 15;12:64. doi: 10.1186/s12985-015-0286-4

Table 4.

Amino acid alignment of the gp51 sequences from 87 isolates based on parsimony-informative sites

LEADERR PEPTIDE 2 CONFORMATIONAL EPITOPE REGIONS 3 ND2 4 T 5 E-B 6 E-D 7 E-A 8
Genotype BLV isolates 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 3 3
1 1 2 2 2 2 2 3 3 4 5 5 5 6 6 7 7 8 8 2 3 3 3 4 4 4 4 8 8 2 3 5 6 7 9 9 9 0 0
7 2 5 3 4 5 8 9 1 7 8 4 6 8 0 9 3 4 0 2 1 2 3 4 0 1 4 6 1 9 9 5 4 7 0 0 1 3 0 1
G1 Korea (Lim, 2009) [24] AY995174 S Q I T L L S R I S A K S S D S A K L S R Q A D A N I F Q S Y S S R F T A S R R
Korea (GBGS-1,2014) KP201466 C V
Korea (GBGS-2,2014) KP201463 C V
Korea (GBGS-3,2014) KP201460 L V
Korea (GBGS-4,2014) KP201468 F C V
Korea (GBGS-6,2014) KP201461 C N V
Korea (GBGS-7,2014) KP201462 N V
Korea (GBGS-10,2014) KP201467 C . L V
Korea (GNCN-1,2014) KP201474 C .
Korea (GNCN-2,2014) KP201472 C .
Korea (GNCN-3,2014) KP201480 C
Korea (GNCN-6,2014) KP201478 C V
Korea (GNCN-8,2014) KP201481 C V F
Korea (GNCN-9,2014) KP201479 C T R V
Korea (GNCN-10,2014) KP201475 P A Q L V
Korea (GNCN-11,2014) KP201482 P A Q L V
Japan (Sagata,1985) [56] K02120 C V
Japan (Zhao, 2007) [30] EF065651 C V
Japan (Zhao, 2007) [30] EF065652 F C Q V
Japan (Zhao, 2007) [30] EF065653 V
Japan (Zhao, 2007) [30] EF065657 C V
Japan (Zhao, 2007) [30] EF065658 C N V
Japan (Zhao, 2007) [30] EF065659 C N V R
Japan (Zhao, 2007) [30] EF065660 C V
Japan (Zhao, 2007) [30] EF065661 C F T V
Japan (Zhao, 2007) [30] EF065662 C V R
Japan (Mekata, unpublished) LC007977* C V R
Japan (Mekata,unpublished) LC007978* C V R
Japan (Mekata,unpublished) LC007979* P C V R
Japan (Mekata, unpublished) LC007980* C V R
Japan (Mekata,unpublished) LC007981* C V R
Japan (Mekata, unpublished) AB934282* C V R
Japan (Mekata, unpublished) LC007983* C V G
Japan (Mekata, unpublished) LC007985* C N V
Japan (Mekata,unpublished) LC007987* C V
Japan (Mekata, unpublished) LC007988* C V
Japan (Mekata, unpublished) LC007989* T C T V
Japan (Mekata, unpublished) LC007990* L V
Japan (Mekata, unpublished) LC007991* V
Japan (Mekata,unpublished) LC007992* T V
USA (Mamoun, 1990) [16] M35239 C V
USA (Mamoun, 1990) [16] M35242 C V
USA (Johnston,2002) [15] AY078387 C V
USA (Zhao, 2007) [30] EF065641 C V
USA (Zhao, 2007) [30] EF065642 C V
USA (Zhao, 2007) [30] EF065644 C V
Costa Rica (Zhao, 2007) [30] EF065637 C V
Costa Rica (Zhao, 2007) [30] EF065640 C V
Uruguay (Moratorio, 2010) [51] FM209468 C N V P
Uruguay (Moratorio, 2010) [51] FM209469 C N V S P
Uruguay (Moratorio, 2010) [51] FM209471 C N V S P
Uruguay (Moratorio, 2010) [51] FM209475 C N V S P
Uruguay (Moratorio, unpublished) HE967301* C N V
Uruguay (Moratorio, unpublished) HE967303* C H N V S
Brazil (Stancek, 2002) [60] AY151262 C N V
Brazil (Stancek, 2002) [60] AF547184 C V C
Brazil (Camargos, 2002) [32] AF399703 V C Q F N V
Australia (Coulston, 1990) [25] D00647 E C Q V
G3 Korea (GBGS-11,2014)KP201464 C Q F T V D L
Korea (GBGS-12,2014)KP201465 C Q F T V D L
USA (Zhao, 2007) [30] EF65647 C Q F T V D L
USA (Zhao, 2007) [30] EF65648 C Q F T V D L
USA (Zhao, 2007) [30] EF65649 C Q F T V D L
Japan (Zhao, 2007) [30] EF65650 C Q F T V D L
Japan (Mekata, unpublished) LC007993* C Q F T V D L
G2 Argentina (Dube, 2000) [54] AF257515 C Q F V D L I S G F K
Argentina (Dube, 2009) [53] FJ914764 C Q T F V D L I K
Brazil (Camargos, 2002) [32] AF399704 C Q F V D L
G8 Russia (Lomakina, unpublished) JQ675760* C P F V L K
Russia (Lomakina, unpublished) JQ675759* C P F V L K
G6 Brazil (Camargos, unpublished) AY185360* E C Q T R F V T L K. I L
G4 Russia (Lomakina, unpublished) JQ686089* C Q T P R F H V G L
Russia (Lomakina,unpublished) JQ686093* C Q T F P R F H V T L
Russia (Lomakina, unpublished) JQ686111* C Q T F P R F H V T L
Belgium (Willems, 1993) [57] AF503581 C Q T A P R F H V N L
Belgium (Zhao, 2007) [30] EF065638 F C Q T P R S F H V L
Belgium (Mamoun, 1990) [16] M35240 C Q T A P R F H V N L
France (Mamoun, 1990) [16] M35238 C Q T F P R F H V T L
Poland (Mikiewicz, unpublished) AF067081* C Q T P R F H V L
G7 Russia (Lomakina, unpublished) JN695880* P C Q T R F V L V
Russia (Lomakina, unpublished) JQ686120* P C Q T R F V L V
Russia (Lomakina, unpublished) JQ675757* C Q I R F V S L V
Moldova (Pluta, unpublished) KF801457* C Q I R F V H L V
Moldova (Pluta,unpublished) KF801458* C Q I R F V C L V
G5 Costa Rica (Zhao, 2007) [30] EF065639 V V C T T R S F R T V L M T
Costa Rica (Zhao, 2007) [30] EF065645 V V C Q T T R S F R V L
Costa Rica (Zhao, 2007) [30] EF065654 V V C Q T T R S F R V L M T

*The Korean strain AY995174 was used as a template to verify amino acid substitutions from BLV sequences found throughout the world. The names of Korean isolates are marked in bold. The dots show homology areas with the template sequence, while amino acid changes are as indicated.

1All isolates were described in the following way: Korean BLV (names, isolation year) and reference BLV (the first author’s name, publication year or unpublished) [reference number] accession number. Unpublished data were marked with an asterisk.

2-7Leader peptide sites (7-31), conformational epitope regions (37-146), second neutralizing domain (ND2) (133-146), CD8+-T epitope (T) (181), various immune-stimulatory epitopes (E) B (229-235), D (254-270), A (290-293), and transmembrane hydrophobic regions (TMHR) (270-293) are shown by amino acid positions previously described in Moratorio et al. [39].