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. 2015 Apr 17;22(1):28. doi: 10.1186/s12929-015-0132-4

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© Aravindan et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Individual gene QPCR analysis showing transcriptional modulations of ATG3, ATG5, ATG7, ATG12, LC3A, LC3B, Belcin1, MyD88, HMGB1, and RAGE in Panc-3.27 and MiaPaCa-2 cells, either mock-irradiated, exposed to FIR (2Gy x 5d) or pretreated with 100 μg/ml of SA-EA, PT-EA, or HT-EA seaweed polyphenol fractions and exposed to FIR. Pretreating the cells with seaweed polyphenols significantly attenuated radiotherapy-induced ATG3, ATG5, ATG7, ATG12, LC3A, LC3B, Belcin1, MyD88, HMGB1, and RAGE transcription in Panc-3.27 and MiaPaCa-2 cells.