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. 2015 Apr 17;22(1):28. doi: 10.1186/s12929-015-0132-4

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© Aravindan et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Seaweed polyphenol treatments regulate autophagy related (ATG3, ATG5, ATG12, LC3A, LC3B, Survivin ) protein expression in radiotherapy resistant residual PC tumors. (A) Images of TMAs labelled (automated IHC) for Blank (no primary antibody), hematoxylin-eosin, ATG3, ATG5, ATG12, LC3A, LC3B, and survivin. (B) Aperio TMA-quantitation analysis showing protein specific positivity magnitudes in mock-irradiated PC xenografts and residual PC tissues after clinical radiotherapy with or without SA-EA, PT-EA, or HT-EA treatment. Group-wise comparisons were made using Two-way ANOVA with Bonferroni’s post-hoc correction.