Extended Data Figure 8. Broad-spectrum cytotoxic T lymphocytes suppress in vivo infection of patient-derived humanized mice with autologous latent HIV-1.

Generation of patient CP36-derived humanized mice was described in Fig. 4. Mice were infected with autologous viruses at 6 weeks old. CD8⁺ T cells from CP36 were pre-stimulated with the mixture of Gag peptides or left untreated for 6 days in vitro and were injected into mice by i.v. 9 days after infection. Plasma HIV-1 RNA and HIV-1 DNA in peripheral blood were measured by real-time PCR.