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. 2015 Apr 22;9:48. doi: 10.3389/fnana.2015.00048

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Copyright © 2015 Li, Yang, Hu, Ling and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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2, 4-diamino-6-hydroxypyrimidine and TP treatments rescued the decreased levels of PI3K, phosphorylated Akt Ser-473, and mTOR induced by ischemia in the cortex and hippocampus, also restored the decreased level of Bcl-2 induced by ischemia. (A) Compared with the control group, the PI3K, Akt, and mTOR protein levels decreased in the MCAO group. And it restored the decreased level of Bcl-2 (B) induced by ischemia DAHP and TP up-regulated the protein levels of PI3K (C), Akt (D), and mTOR (E). **P < 0.01 vs. MCAO group; ##P < 0.01 vs. MCAO group; #P < 0.05 vs. MCAO group.