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. 2015 Apr 22;9:140. doi: 10.3389/fnins.2015.00140

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Copyright © 2015 Weth, Benetti, Rauch, Gstraunthaler, Schmidt, Geisslinger, Sabbadini, Proia and Kress.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activated platelets increased thermal sensitivity in vivo. (A) After intracutaneous injection of platelet preparations (10 μl) in different concentrations a dose-dependent reduction of paw withdrawal latency (PWL) was observed. Heat sensitization recovered to baseline after 24 h. (B) Injection of the supernatant of sonicated platelets led to a reduction in PWL as well. (C) Quantification of PWL shown in (A,B) 1 h after injection (^*p < 0.05, ^**p < 0.01, ^***p < 0.001; Mann Whitney U-test). (D) S1P concentration in platelet preparations as measured with HPLC. S1P concentration was directly proportional to platelet concentration (^*p < 0.05, ^**p < 0.01; Mann Whitney U-test).