Table 2.

In vivo evidence of H-1PV oncoselectivity.

Tumor (Tu)	H-1PV adm. route	Normal tissue (N)a	Tu versus N sensitization to H-1PV infection	Reference
Rat/human pancreatic carcinoma	i.t.	Normal pancreatic and other visceral tissues	Long-lasting H-1PV expression in Tu Transient H-1PV expression in N; no virus-induced changes in blood, liver, and kidney clinical parameters	Angelova et al. (2009b) and Li et al. (2013)
Rat/human glioma	i.t.	Normal brain and other visceral tissues	Late H-1PV expression in residual Tu; Tu-dependent H-1PV production in brain	Di Piazza et al. (2007), Geletneky et al. (2010), and Kiprianova et al. (2011)
	i.v.
	i.n.		Transient virus genome detection, no late virus expression and no pathological alterations in N
Human cervical carcinoma	i.t.	Normal visceral tissues	Selective NS1 expression in Tu No weight loss or other side effects	Li et al. (2013)
Immunocomp. Tu-free rats	i.v.	Visceral tissues	Broad organ distribution and time-dependent decrease of H-1PV genomes	Geletneky et al. (2015a,b)
	i.c.
			No or minimal and reversible toxicological changes

^aTreated animals were immunocompetent (no tumor or rat tumor grafts) or nude (human tumor xenografts) rats.

i.t., intratumoral; i.v., intravenous; i.n., intranasal; i.c., intracerebral.