Table 4.

IHC staining indices of the HER2 pathway markers and percentages of the Ki67-positive cells in the baseline tumors^*

	PR (N=2)		SD/PD (N=6)
Markers	Median	Range	Median	Range
pHER2-Y1248	56.0	54.3–57.7	3.7	0–44.0**
pHER2-Y877	38.8	33.4–44.1	3.3	0–44.5
pMAPK	56.6	42.4–70.8	33.7	12.9–90.1
pAkt	13.5	4.2–22.7	1.6	0–36.8
HER2	64.3	61.6–67.1	74.6	18.7–91.5
Ki67†	49.4	37.2–61.6	57.4	18.6–95.3

^*IHC staining index = (staining intensity of a sample – staining intensity of negative control) × percentage of stained cells /100. (30)

^**p-value = 0.095

^†Percentages of IHC stained cells.

Abbreviations: IHC, immunohistochemistry; PR, partial response; SD, stable disease; PD, progressive disease.