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. Author manuscript; available in PMC: 2015 Apr 22.
Published in final edited form as: Vaccine. 2013 Oct 5;31(48):5713–5721. doi: 10.1016/j.vaccine.2013.09.040

Figure 5. DVG-derived naked RNA trigger RIG-I signaling.

Figure 5

WT and RIG-I KO MEFs were transfected with 1 µg of CpG or with increasing doses of poly I:C or in vitro transcribed DVG-324 as indicated. Total RNA was extracted 8 h later and expression of Ifnb mRNA was determined by RT-qPCR. Data corresponds to the average of three experiments. p=0.0001 by one-way ANOVA with Bonferroni post-hoc test. Significance after Bonferroni post-hoc test among different conditions is indicated in the graphs as ****=p<0.0001. Bonferroni denominator = 12. Data are expressed as copy numbers relative to the housekeeping genes Actb and Tuba1b.