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. 2015 Apr 10;15:250. doi: 10.1186/s12885-015-1291-0

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© Shakibaei et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Electron microscopic demonstration of alginate beads with HCT116 spheroids. The HCT116 cells are embedded (A) and divided (B-C) in alginate beads (*) after 3-7days. They move apart forming more and more aggregates (arrow) and a capsule. The round to oval HCT116 cells cultured in alginate for 10-14 days (D-E), showing cell aggregates within a channel (arrows), proliferating cells emigrating from the beads. Numerous cells were apoptotic and fragmented (arrowheads). x4.500.