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. 2015 Apr 10;15:250. doi: 10.1186/s12885-015-1291-0

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© Shakibaei et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Curcumin increases 5-FU to block the proliferation and viability of HCT116 (a) and HCT116R (b) cells (1 × 10⁶/ml) cultured in alginate beads. Phase-contrast microscopic observations after 14 days of HCT116 cells (a: A, B, C) (arrows), and HCT116R cells (b: A, B, C) (arrows) in alginate showed the inhibition of formation of spheroids and viability of cells by curcumin, 5-FU alone and in combination of them in serum-starved medium. Samples from 3 experiments were analyzed and representative data are shown. x24, bar=0.2 mm in all cases.