Table 3.

A summary of changes in molecular expression as a result of uterine artery ligation

Molecule	Function	Expression in uterine artery ligation
Bcl-2	Anti-apoptotic protein	Reduced (ventricular zone)
p53	Pro-apoptotic protein	Increased (cortical zone, CA1 region, subcortical and periventricular white matter, the amygdala)
Phosphor-p53	Pro-apoptotic protein	Increased (cortical zone, CA1 region, subcortical and periventricular white matter, the amygdala)
Murine double minute 2	Mitigates apoptosis due to p53	Reduced
Bcl-2-associated X protein	Pro-apoptotic protein	Increased
Caspase-3	DNA fragmentation	Increased
Inducible NOS	Cerebral pathology associated with apoptosis	Increased (parietal cerebral cortex, ventricular zone)
Endothelial NOS	Cerebral pathology associated with apoptosis	Increased (ventricular zone)
BDNF	Support of neuronal survival, differentiation, and growth	Reduced (hippocampus)
TrkB receptor	Activated by BDNF to support neuronal growth/development	Reduced (hippocampus)
ErbB3 receptor	Cellular differentiation and proliferation	Reduced (hippocampus)
NMDA receptor subunits	Cognitive and memory development	Reduced NR1 expression and NR2A–NR2B ratio (hippocampus)

Bcl-2, B-cell lymphoma 2; BDNF, brain-derived neurotrophic factor; NMDA, N-methyl-D-aspartate; NOS, nitric oxide synthase; TrkB, tyrosine kinase receptor.