Table 1.
Unadjusted mean performance on the Mattis Dementia Rating Scale and the CERAD Neuropsychological Assessment Battery as a function of ApoE ε4 statusa
| ApoE ε4 positive
|
ApoE ε4 negative
|
||||
|---|---|---|---|---|---|
| Mean (SD) | Range | Mean (SD) | Range | P | |
| Mattis Dementia Rating Scale (maximum possible points) | |||||
| Total score (144) | 97.1 (17.2) | 55–122 | 94.3 (17.6) | 64–123 | 0.57 |
| Attention (37) | 31.6 (3.6) | 22–37 | 31.6 (4.4) | 22–37 | 0.98 |
| Initiation/perseveration (37) | 24.4 (7.4) | 8–36 | 22.1 (6.7) | 10–34 | 0.25 |
| Construction (6) | 3.7 (1.6) | 1–6 | 4.1 (1.6) | 2–6 | 0.47 |
| Memory (25) | 10.8 (3.2) | 3–21 | 10.8 (3.3) | 5–18 | 0.99 |
| Conceptualization (39) | 26.5 (7.3) | 5–37 | 24.8 (6.2) | 15–34 | 0.39 |
| CERAD | |||||
| Animal fluency (no limit) | 8.3 (3.0) | 4–16 | 7.2 (3.1) | 2–12 | 0.25 |
| Boston Naming Test (15) | 8.8 (2.6) | 4–14 | 8.8 (2.4) | 5–14 | 0.99 |
| Constructional praxis (11) | 5.7 (2.5) | 1–11 | 6.9 (1.4) | 5–10 | 0.09 |
| Immediate total recall (30) | 9.0 (3.8) | 3–17 | 8.4 (3.2) | 4–14 | 0.61 |
| Delayed total recall (10) | 0.5 (0.9) | 0–3 | 0.5 (0.9) | 0–2 | 0.96 |
a
SD, standard deviation; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease.