Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of novobiocin mimics that contain a substituted biphenyl moiety.
Reagents and conditions: a Pd(dppf)2Cl2, 2M K2CO3, Dioxane, 110 °C, 12 h, 17%%~74%; b Ph3P, DIAD, THF, r. t., 12 h, 46%~80%; c Pd/C, MeOH, r. t., 2 h, 100%; d pyridine, DCM, r. t., 4 h, 39%~87%.
