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Western blot analyses of Hsp90-dependent client proteins from MCF-7 breast cancer cell lysate upon treatment with biphenyl derivatives. Concentrations (in μM) were indicated above each lane. H represents a concentration equal to 5-fold of the anti-proliferative activity. L represents a concentration equal to 0.5-fold of the anti-proliferative activity. Geldanamycin (G, 0.5 μM) and dimethylsulfoxide (D, 100%) were employed as positive and negative controls.
