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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Eur J Med Chem. 2014 Oct 14;89:442–466. doi: 10.1016/j.ejmech.2014.10.034

Scheme 3.

Scheme 3

Synthesis of pyridine biphenyl derivatives.

Reagents and conditions: a Ph3P, DIAD, THF, r. t., 12 h, 58%~68%; b Pd(dppf)2Cl2, 2M K2CO3, Dioxane, 110 °C, 12 h, 75%%~92%; c Pd/C, MeOH, r. t., 2 h, 100%; d pyridine, DCM, r. t., 4 h, 45%~87%.