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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Eur J Med Chem. 2014 Oct 14;89:442–466. doi: 10.1016/j.ejmech.2014.10.034

Table 1.

Anti-proliferative activity of novobiocin mimics.

graphic file with name nihms-639562-t0016.jpg

Entry Biphenyl R SKBr3
(IC50, μM)		 MCF-7
(IC50, μM)
5 -- -- ~700 --
6 -- -- 0.76±0.14 a 1.09±0.08
7 -- -- 0.39±0.06 0.37±0.05
8a para-meta A (R1 = OAc) 3.47±0.47a 2.71±0.40
8b meta-meta A (R1 = OAc) 1.76±0.16 1.70±0.21
8c para-para A (R1 = OAc) 1.82±0.21 1.37±0.18
8d para-meta A (R1 = OH) 2.94±0.11 2.21±0.06
8e meta-meta A (R1 = OH) 2.79±0.40 1.17±0.05
8f para-para A (R1 = OH) 2.27±0.08 1.85±0.32
8g para-meta B 3.65±0.14 1.25±0.02
8h meta-meta B 1.62±0.07 2.00±0.07
8i para-para B 0.47±0.06 0.71±0.02
a

Values represent mean ± standard deviation for at least two separate experiments performed in triplicate.