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Anti-proliferative activity manifested by pyridine biphenyl derivatives.
| Entry | W | X | Y | Z | SKBr3 (IC50, μM) |
MCF-7 (IC50, μM) |
|---|---|---|---|---|---|---|
| 8i | C | C | C | C | 0.47±0.06 | 0.71±0.02 |
| 19a | N | C | C | C | 1.67±0.09 | 1.56±0.19 |
| 19b | C | N | C | C | 1.91±0.21 | 1.30±0.15 |
| 19c | C | C | N | C | 1.21±0.13 | 1.02±0.01 |
| 19d | C | C | C | N | 1.07±0.01 | 1.15±0.16 |
