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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Eur J Med Chem. 2014 Oct 14;89:442–466. doi: 10.1016/j.ejmech.2014.10.034

Table 3.

Anti-proliferative activity manifested by substituted biphenyl derivatives.

graphic file with name nihms-639562-t0018.jpg

Entry R1 R2 R3 R4 SKBr3
(IC50, μM)		 MCF-7
(IC50, μM)
8i H H H H 0.47±0.06 0.71±0.02
29a Me H H H 0.83±0.03 1.69±0.08
29b H Me H H 1.18±0.11 1.21±0.03
29c H H Me H 0.97±0.01 1.57±0.56
29d H H H Me 2.47±0.39 1.43±0.35
29e OMe H H H 0.68±0.13 1.32±0.08
29f H OMe H H 1.41±0.35 1.35±0.16
29g H H OMe H 0.90±0.08 1.50±0.08
29h H H H OMe 3.92±0.21 1.22±0.04
29i Cl H H H 1.84±0.57 1.48±0.12
29j H Cl H H 1.28±0.14 1.48±0.33
29k H H Cl H 2.21±0.18 3.44±0.21
29l H H H Cl 4.29±0.65 1.80±0.19
34a NO2 H H H 2.07±0.17 1.23±0.25
34b H NO2 H H 1.18±0.15 1.30±0.12
34c H H NO2 H 2.48±0.77 3.32±0.25
34d H H H NO2 3.40±0.14 1.15±0.01
38a NH2 H H H 2.23±0.49 5.95±1.22
38b H NH2 H H 2.13±0.06 1.76±0.37
38c H H NH2 H 3.90±0.18 2.07±0.23
38d H H H NH2 3.21±0.45 2.25±0.49
39a NHAc H H H 2.66±0.76 1.84±0.43
39b H NHAc H H 3.39±0.66 1.36±0.23
39c H H NHAc H 2.52±0.26 4.66±0.49
39d H H H NHAc 3.51±0.56 1.66±0.59