Table 4.
Anti-proliferative activity manifested by biphenyl derivatives that contain a modified benzylamide side chain.
| Entry | R | SKBr3 (IC50, μM) | MCF-7 (IC50, μM) |
|---|---|---|---|
| 41a | phenyl | 4.13±0.22 | 3.95±0.13 |
| 41b | 4-chlorophenyl | 0.57±0.01 | 0.52±0.03 |
| 41c | 4-bromophenyl | 0.52±0.21 | 0.52±0.15 |
| 41d | 4-iodophenyl | 0.31±0.09 | 0.58±0.01 |
| 41e | 4-methylphenyl | 0.98±0.19 | 1.27±0.13 |
| 41f | 4-methoxyphenyl | 0.49±0.01 | 0.65±0.04 |
| 41g | 4-t-butylphenyl | 1.26±0.37 | 1.08±0.08 |
| 41h | 3-chlorophenyl | 1.94±0.37 | 2.83±0.69 |
| 41i | 3 -methoxyphenyl | 2.87±0.51 | 5.31±0.70 |
| 41j | 3 -methyl -4 -chl orophenyl | 1.11±0.42 | 1.03±0.16 |
| 41k | 3-chloro-4-methylphenyl | 1.96±0.24 | 2.28±0.49 |
| 41l | 3 -bromo-4-methylphenyl | 2.80±0.18 | 3.35±0.36 |
| 41m | 3-iodo-4-methylphenyl | 0.93±0.20 | 1.17±0.20 |
| 41n | 3,4-dichl orophenyl | 1.20±0.08 | 1.60±0.16 |
| 41o | 3,5-dichl orophenyl | 0.81±0.28 | 1.68±0.13 |
| 41p | 2,4-dichlorophenyl | 0.80±0.22 | 1.37±0.33 |
| 41q | 2-biphenyl | 6.26±1.54 | 6.67±0.83 |
| 41r | 3-biphenyl | 0.73±0.07 | 1.15±0.18 |
| 41s | 4-biphenyl | 4.59±0.06 | 4.44±0.60 |
| 43a | 1-naphthoyl | 0.22±0.13 | 0.58±0.02 |
| 43b | 2-naphthoyl | 0.35±0.02 | 0.49±0.11 |
| 45a | 2-quinolinyl | 2.42±0.62 | 2.76±0.76 |
| 45b | 6-quinolinyl | 1.31±0.18 | 2.07±0.16 |
| 47a | 2-indolyl | 0.64±0.08 | 0.58±0.02 |
| 47b | 2-benzo[b]thiophenyl | 1.32±0.23 | 2.01±0.58 |
| 8i | -- | 0.47±0.06 | 0.71±0.02 |