Skip to main content
. Author manuscript; available in PMC: 2015 Apr 22.
Published in final edited form as: Adv Pharmacol. 2014;69:129–176. doi: 10.1016/B978-0-12-420118-7.00004-4

Figure 2.

Figure 2

Effects of acute IM pretreatments with the SERT inhibitors fluoxetine or citalopram on cocaine-induced reinstatement of extinguished cocaine self-administration in rhesus monkeys (N=3). Subjects were trained to self-administer cocaine under a second-order schedule and could take a maximum of 0.5 mg/kg per session 5 days per week. Subsequently, saline was substituted for cocaine, and once extinction criteria were met (response rates <20% of cocaine-maintained rates), response-independent cocaine (0.1mg/kg) was administered IV prior to extinction sessions. Both fluoxetine and citalopram significantly attenuated cocaine-induced reinstatement (* p <0.05 with respect to control).