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. Author manuscript; available in PMC: 2015 Apr 22.
Published in final edited form as: Adv Pharmacol. 2014;69:129–176. doi: 10.1016/B978-0-12-420118-7.00004-4

Figure 5.

Figure 5

Effects of 14-day treatment with either amphetamine or phendimetrazine on choice between cocaine and food by rhesus monkeys. Cocaine injections and food pellets were available simultaneously during daily experimental sessions consisting of five sequential components, with the available cocaine dose increasing from 0 (no injection) to 0.1 mg/kg/injection across components. Continuous infusion with amphetamine (N=6) or phendimetrazine (N=4) produced rightward shifts in the cocaine-choice dose-effect curve and promoted reallocation of behavior away from cocaine choice and toward food choice. Filled points indicate a significant effect of amphetamine or phendimetrazine vs. saline as determined by two-way analysis of variance followed by the LSD multiple comparisons post hoc test. Notations of “N=5” in the left panel indicate that five of six monkeys contributed to the point during treatment with 0.1 mg/kg/hr amphetamine, and one monkey failed to respond for either food or cocaine. Adapted from Banks et al., 2013.