Table 1.

Neurobiological Effects of Chronic Cocaine Administration in Nonhuman Primates and Humans

Effect	Nonhuman Primates	Humans
Dopamine Transporter	↑ Letchworth, et al., 2001 = Czoty, et al., 2007	↑ Little, et al., 1993 ↑ Staley, et al., 1994
Dopamine D1 Receptor	↓ Moore, et al., 1998a ↓ Nader, et al., 2002	= Martinez, et al., 2009
Dopamine D2 Receptor	↓ Moore, et al., 1998b ↓ Nader, et al., 2002 ↓ Czoty, et al., 2004	↓ Volkow and Fowler, 2000 ↓ Volkow, et al., 2001a
Dopamine Release	↓ Kirkland Henry, et al., 2009	↓ Martinez, et al., 2007 ↓ Volkow, et al., 1997
Serotonin Transporter	↑ Banks, et al., 2008 ↑ Gould, et al., 2011	↑ Jacobsen, et al., 2000 ↑ Mash, et al., 2000
Serotonin 5HT2A Receptor	↑ Sawyer, et al., 2012
Norepinephrine Transporter		↑ Ding, et al., 2010
Distribution of Cerebral Activation	↑ Henry, et al., 2010
Cerebral Perfusion		↓ Volkow, et al., 1998
Cerebral Metabolism		↓ Reivich, et al., 1985 ↓ Volkow, et al., 2001a