Table 4.
Sample Characteristics (N = 128)
| Characteristic | Chemotherapy Plus Anastrozole (n = 37)
|
Anastrozole Alone (n = 41)
|
Healthy Controls (n = 50)
|
pa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ε4 (n = 11)
|
No ε4 (n = 26)
|
ε4 (n = 9)
|
No ε4 (n = 32)
|
ε4 (n = 16)
|
No ε4 (n = 34)
|
||||||||
| X̄ | SD | X̄ | SD | X̄ | SD | X̄ | SD | X̄ | SD | X̄ | SD | ||
| Age (years) | 58.64 | 4.61 | 58.5 | 5.666 | 61.56 | 4.613 | 61.03 | 5.608 | 60.25 | 6.557 | 57.5 | 5.594 | 0.112 |
| Years of education | 16.27 | 3.349 | 15.42 | 2.595 | 15.67 | 2.958 | 14.97 | 3.605 | 15 | 2.633 | 14.94 | 3.428 | 0.847 |
| Estimated intelligence (NART) | 110.58 | 7.299 | 108.2 | 9.754 | 109.22 | 6.378 | 105.92 | 9.516 | 115.368 | 9.373 | 113.52 | 7.375 | 0.002* |
| T0 depression (BDI–II) | 3.09 | 2.625 | 5.85 | 5.655 | 3 | 2.291 | 5.34 | 6.378 | 4.06 | 4.669 | 4.88 | 4.848 | 0.548 |
| T0 anxiety (POMS tension/anxiety) | 10.64 | 7.514 | 9.45 | 5.896 | 6.44 | 3.245 | 7.16 | 4.712 | 6.13 | 5.084 | 6.79 | 6.188 | 0.145 |
| T0 fatigue (POMS fatigue/inertia) | 3.91 | 4.061 | 6.23 | 6.855 | 2.78 | 3.346 | 5.69 | 6.188 | 5 | 6.501 | 5.12 | 5.139 | 0.674 |
| T0 pain (BPI Right Now) | 0.91 | 1.375 | 1.69 | 2.112 | 1.56 | 1.74 | 1.28 | 1.955 | 0.63 | 1.544 | 1.21 | 2.307 | 0.638 |
|
| |||||||||||||
| Characteristic | n | n | n | n | n | n | pa | ||||||
|
| |||||||||||||
| Married | 7 | 20 | 5 | 24 | 8 | 22 | 0.433 | ||||||
| Children | 8 | 23 | 7 | 27 | 13 | 31 | 0.678 | ||||||
| Caucasian | 10 | 25 | 9 | 32 | 15 | 33 | 0.672 | ||||||
| Cancer stage | |||||||||||||
| • I | 8 | 11 | 8 | 25 | – | – | – | ||||||
| • IIa | 3 | 10 | – | 7 | – | – | |||||||
| • IIb | – | 3 | 1 | – | – | – | |||||||
| • IIIa | – | 2 | – | – | – | – | |||||||
*
p < 0.05
a
One-way analysis of variance was used to compare study cohort means of continuous variables. Pearson’s chi-square tests of independence was used to examine the general associations between categorical variables.
BDI–II—Beck Depression Inventory–II; BPI—Brief Pain Inventory; NART—National Adult Reading Test–Revised verbal IQ score; POMS—Profile of Mood States
Note. At baseline, participants were not experiencing depression, anxiety, fatigue, or pain. Although not significant, women in the chemotherapy plus anastrozole group had somewhat higher anxiety scores at baseline.