Table 6.

Cognitive Factors With Significant Longitudinal Change Score Results

Time and Model	APOE ε4 Presence		APOE ε4 Presence by Chemotherapy Plus Anastrozole Interaction		APOE ε4 Presence by Anastrozole Alone Interaction
	β	p	β	p	β	p
Visual Learning and Memory
T0–T1 (n = 124)
Interaction	0.1375	0.371	0.209	0.402	−0.1525	0.548
Main effects	0.154	0.133
T0–T2 (n = 112)
Interaction	0.0498	0.76	0.1082	0.681	−0.567	0.042*
Main effects	−0.0604	0.592
T1–T2 (n = 111)
Interaction	−0.087	0.622	−0.1782	0.542	−0.5112	0.088*
Main effects	−0.269	0.027*
Verbal Learning and Memory
T0 –T1 (n = 124)
Interaction	−0.0651	0.722	0.4485	0.133	−0.0911	0.763
Main effects	0.0347	0.777
T0–T2 (n = 112)
Interaction	−0.1261	0.486	0.5468	0.064*	0.1539	0.616
Main effects	0.0717	0.562
T1–T2 (n = 111)
Interaction	−0.0428	0.811	0.053	0.857	0.1105	0.713
Main effects	0.0005	0.997
Attention
T0–T1 (n = 124)
Interaction	0.0409	0.785	−0.258	0.29	0.1385	0.576
Main effects	0.0069	0.945
T0–T2 (n = 112)
Interaction	0.1523	0.375	−0.2949	0.289	−0.3997	0.171
Main effects	−0.0336	0.773
T1–T2 (n = 111)
Interaction	0.1539	0.359	−0.1669	0.547	−0.5715	0.045*
Main effects	−0.0408	0.722

^*p < 0.1; estimates controlled for age, estimated intelligence, depression, anxiety, fatigue, and pain change scores.

APOE–apolipoprotein E

Note. The healthy control cohort and women with no ε4 alleles served as the reference groups in the analysis.