Table 6.
Time and Model | APOE ε4 Presence
|
APOE ε4 Presence by Chemotherapy Plus Anastrozole Interaction
|
APOE ε4 Presence by Anastrozole Alone Interaction
|
|||
---|---|---|---|---|---|---|
β | p | β | p | β | p | |
Visual Learning and Memory | ||||||
| ||||||
T0–T1 (n = 124) | ||||||
Interaction | 0.1375 | 0.371 | 0.209 | 0.402 | −0.1525 | 0.548 |
Main effects | 0.154 | 0.133 | ||||
| ||||||
T0–T2 (n = 112) | ||||||
Interaction | 0.0498 | 0.76 | 0.1082 | 0.681 | −0.567 | 0.042* |
Main effects | −0.0604 | 0.592 | ||||
| ||||||
T1–T2 (n = 111) | ||||||
Interaction | −0.087 | 0.622 | −0.1782 | 0.542 | −0.5112 | 0.088* |
Main effects | −0.269 | 0.027* | ||||
| ||||||
Verbal Learning and Memory | ||||||
| ||||||
T0 –T1 (n = 124) | ||||||
Interaction | −0.0651 | 0.722 | 0.4485 | 0.133 | −0.0911 | 0.763 |
Main effects | 0.0347 | 0.777 | ||||
| ||||||
T0–T2 (n = 112) | ||||||
Interaction | −0.1261 | 0.486 | 0.5468 | 0.064* | 0.1539 | 0.616 |
Main effects | 0.0717 | 0.562 | ||||
| ||||||
T1–T2 (n = 111) | ||||||
Interaction | −0.0428 | 0.811 | 0.053 | 0.857 | 0.1105 | 0.713 |
Main effects | 0.0005 | 0.997 | ||||
| ||||||
Attention | ||||||
| ||||||
T0–T1 (n = 124) | ||||||
Interaction | 0.0409 | 0.785 | −0.258 | 0.29 | 0.1385 | 0.576 |
Main effects | 0.0069 | 0.945 | ||||
| ||||||
T0–T2 (n = 112) | ||||||
Interaction | 0.1523 | 0.375 | −0.2949 | 0.289 | −0.3997 | 0.171 |
Main effects | −0.0336 | 0.773 | ||||
| ||||||
T1–T2 (n = 111) | ||||||
Interaction | 0.1539 | 0.359 | −0.1669 | 0.547 | −0.5715 | 0.045* |
Main effects | −0.0408 | 0.722 |
p < 0.1; estimates controlled for age, estimated intelligence, depression, anxiety, fatigue, and pain change scores.
APOE–apolipoprotein E
Note. The healthy control cohort and women with no ε4 alleles served as the reference groups in the analysis.