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Schematic representing the proposed events following administration of formulation containing Tx- and TPT-loaded PLGA–chitosan composite particles to an in vitro grown 3-D tumoroid.
Note: The up arrows indicate an increase in BcL-xL phosphorylation and topoisomerase 1 levels.
Abbreviations: 3-D, three-dimensional; PLGA, poly(d,l-lactide-co-glycolide); TPT, topotecan; Tx, paclitaxel.
