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. 2015 Apr 16;10:2997–3011. doi: 10.2147/IJN.S78120

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© 2015 Arya and Katti. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Isobologram of TPT and Tx on NCI-H460 cells demonstrating equitoxic doses of TPT and Tx either alone or in combination (simultaneous or sequential).

Notes: The diagonal line connects IC₅₀ values of TPT and Tx and represents zero interaction isoboles. Values on the right side of the diagonal line indicate an antagonistic interaction between the drugs (simultaneous treatment), while those on the left side of the diagonal line indicate a synergistic interaction (sequential treatment).

Abbreviations: IC₅₀, half maximal inhibitory concentration; TPT, topotecan; Tx, paclitaxel.