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. 2015 Apr 16;10:2997–3011. doi: 10.2147/IJN.S78120

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© 2015 Arya and Katti. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cell viability (percentage of control) of NCI-H460 tumoroids generated on 3-D chitosan–gelatin scaffolds following treatment with Tx (5 hours), TPT (after 24 hours), Tx followed by TPT, TPT-loaded PLGA–chitosan composite microparticles, and combination of Tx- and TPT-loaded PLGA–chitosan composite particles.

Notes: Tx and TPT concentrations were 100 and 500 nM, respectively. *Indicates significance (P<0.05) between additive effect of Tx and TPT when treated individually vs their sequential treatment. **Indicates significance (P<0.05) between additive effect of Tx- and TPT-loaded PLGA–chitosan composite particles (Tx + PLGA-TPT-Ch-P) when treated individually vs their combination on NCI-H460 tumoroids. n=3.

Abbreviations: 3-D, three-dimensional; Ch-P, chitosan micro-/nanoparticles; PLGA, poly(d,l-lactide-co-glycolide); TPT, topotecan; Tx, paclitaxel.