Table 2.

Chromosome enrichment identified regions that contain groups of genes that preferentially are increased or decreased in ADLD patients

ADLD increased					ADLD decreased
CHR	Cytoband	NES	NOM p-val	FDR q-val	CHR	Cytoband	NES	NOM p-val	FDR q-val
1	1p31	1.74	0.002	0.099	1	1q44	−1.61	0.006	0.137
	1p32	1.59	0.002	0.220	4	4p12	−1.58	0.026	0.160
	1p34	1.60	0.000	0.230		4p14	−1.51	0.035	0.245
2	2q13	1.81	0.002	0.223		4q13	−1.65	0.000	0.109
	2q34	1.78	0.002	0.111	6	6p22	−1.77	0.004	0.007
	2p23	1.53	0.015	0.247		6p23	−1.80	0.004	0.152
6	6p25	1.75	0.002	0.118	7	7q36	−1.67	0.000	0.109
9	9p21	1.80	0.000	0.136
11	11p13	1.56	0.028	0.200
	11q13	1.59	0.000	0.200
15	15q22	1.59	0.008	0.190
	15q23	1.59	0.019	0.175

NES, normalized enrichment score (analyzed using GO gene sets in the GSEA software); NOM p-val, nominal P-value; FDR q-val, false discovery rate, nominal P-value corrected for multiple hypotheses testing. Only gene sets with FDR q-val <0.25 and NOM p-val <0.05 are shown.

Positional gene set analysis was performed by using GSEA.