Table 1.
Locus | Population | Control MAF | Control genotype counts |
Case MAF | Case genotype counts |
P-valuea | ORb | 95% CIb | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
rs10816625 | AA | AG | GG | AA | AG | GG | ||||||
9q31.2 | Caucasians | 0.06 | 37579 | 4851 | 169 | 0.07 | 37 434 | 5560 | 164 | 7.89 × 10−09 | 1.12 | 1.08–1.17 |
110 837 073 | Asians | 0.38 | 2633 | 2976 | 1013 | 0.42 | 2023 | 2714 | 1057 | 2.77 × 10−05 | 1.12 | 1.06–1.18 |
rs13294895 | GG | AG | AA | GG | AG | AA | ||||||
9q31.2 | Caucasians | 0.20 | 28 954 | 12 372 | 1272 | 0.19 | 28 625 | 13 029 | 1506 | 2.97 × 10−11 | 1.09 | 1.06–1.12 |
110 837 176 | Asians | 0.03 | 6244 | 372 | 8 | 0.03 | 5495 | 288 | 10 | 0.66 | 1.04 | 0.89–1.21 |
rs676256 | AA | AG | GG | AA | AG | GG | ||||||
9q31.2 | Caucasians | 0.38 | 16166 | 20183 | 6250 | 0.36 | 18 011 | 19 670 | 5472 | 1.58 × 10−25 | 0.90 | 0.88–0.92 |
110 895 353 | Asians | 0.05 | 6036 | 567 | 21 | 0.04 | 5329 | 455 | 11 | 0.3 | 0.94 | 0.82–1.06 |
aP-values from single SNP test of association, computed from a likelihood-ratio test with one degree-of-freedom.
bOdds ratios and 95% confidence intervals for SNP association with breast cancer estimated using logistic regression, adjusting for study and significant principal components and assuming multiplicativity on the odds scale for heterozygote and minor-allele homozygote ORs.